Endocrine Abstracts

Introduction: The presence of diabetes-associated antibodies is an indicator of β-cell destruction. Our goal was to find out the prevalence of autoantibodies associated with the new onset of type 1 diabetes mellitus (DM1) without family history.Subjects and Methods: 22 patients (10 women and 12 men) with newly diagnosed DM1 no family history were examined. Average age of patients was 31.7±7.3 y.o., experience of DM1 was 2.3±0.8 months. All the...

Introduction: Preserving of C-peptide secretion in type 1 diabetes mellitus (DM1) is an important goal in treatment, as it provides the possibility of optimal compensation. We initiated a study (ClinicalTrials.gov 26.01.2022, NCT05207995) to assess the potential effect of Tolerant Dendritic Cells (tolDC) on the newly diagnosed DM1.Methods: Evaluation of stimulated C-peptide against the background of a standard breakfast (carbohydrate content of 50g) was ...